O The Municipality of Santarém possesses a geographical position of great centrality in relation to the main cities of Mainland Portugal and neighboring Spain. Santarém is thus connected by the following routes:
Porto (with connections to Coimbra and Aveiro) – A1 (245 km – approximately 2h15)
Vila Real (with connections to Viseu) – A1, A25, and A24 (361 km approximately – 3h38m)
Bragança (with connections to Castelo Branco, Covilhã, and Guarda) – A23 (423 km – approximately 4h09m)
Lisbon – A1 (80 km – approximately 1h)
Évora – A13 and A6 (163 km approximately – 1h37m)
Beja – A13, A2 and IP8 (207 km approximately – 2h04m)
Faro – A13 and A2 (307 km; approximately – 2h40m)
Madrid – A1 and A23 in Portugal and Autovía del Suroeste/Paseo de Extremadura/A-5 in Spain (530 km approximately 5h30)
Seville (via Badajoz) – A13, A6 in Portugal and A66 in Spain (477 km approximately 4h34)
Santiago de Compostela (via Valença) – A1 and A3 in Portugal and AP-9 in Spain (472 km approximately 4h27)
Caldas da Rainha (connection to the Coast) – A15 (55 km approximately 40 minutes)